Research

Awarded fellowships

iCARE-2 fellows whose fellowship has already started are listed below.

Carotenuto Pietro

Fondazione Telethon, Italy

Cassani Marco

St. Anne's university Hospital in Brno, Czech republic

“Mechanobiology-mediated nanoparticles-cells interactions to develop immunotherapy against breast cancer.”

Fellowship type: Outgoing

Year awarded: 2019

See the achivement

Cioni Bianca

Fondazione I.R.C.C.S. Istituto Nazionale dei Tumori, Italy

“JMJD6-mediated Regulation of Hormonal Receptors in Breast and Prostate Cancer”

Fellowship type: Reintegration

Year awarded: 2019

Conway Eric

Istituto Europeo di Oncologia I.R.C.C.S. S.r.l, Italy

“Uncovering the Mode of Action of PRC2 mutations in T-ALL Development and Resistance to Targeted Therapy”

Fellowship type: Incoming

Year awarded: 2018

See the achivement

Cortesi Filippo

Universitaetsklinikum Hamburg-Eppendorf, Germany

“Unravel tumor-specific iNKT cell plasticity: from underlying mechanisms to targets”

Fellowship type: Outgoing

Year awarded: 2018

Desideri Enrico

Università degli Studi di Roma "Tor Vergata", Italy

“Role of Chaperone-Mediated Autophagy in Hepatocellular Carcinoma”

Fellowship type: Reintegration

Year awarded: 2018

See the achivement

Ficht Xenia Maria

Fondazione Centro San Raffaele, Italy

“Therapeutic potential of tissue-resident memory T cells in hepatocellular carcinoma”

Fellowship type: Incoming

Year awarded: 2019

See the achivement

Landolina Nadine

Ospedale Pediatrico Bambino Gesù, Italy

“IL-37/ TIR8: a crucial checkpoint in human NK cell function and anti-tumor activity”

Fellowship type: Reintegration

Year awarded: 2019

Lubrano Simone

The Regents of University of California, La Jolla USA

“Targeting the novel Gαq-FAK-Hippo signaling circuitry for ocular melanoma precision therapy”

Fellowship type: Outgoing

Year awarded: 2019

See the achivement

Massara Matteo

University of Lausanne, Switzerland

“Elucidating the education and function of recruited macrophages and resident microglia in brain metastasis”

Fellowship type: Outgoing

Year awarded: 2018

Nica Valentin

Fondazione Istituto Italiano di Tecnologia, Italy

“Development of novel approaches using trimagnetic nanoparticles for intracellular hyperthermia of prostate cancer cells”

Fellowship type: Incoming

Year awarded: 2019

Pseftogas Athanasios

Università Vita-Salute San Raffaele, Italy

“Investigation of the role of Cyld tumor supressor in marginal zone B-cell lymphoma”

Fellowship type: Incoming

Year awarded: 2018

Rangan Priya

Fondazione Centro San Raffaele, Italy

“Dissecting the contribution of the microbiome to immune-radiotherapy of prostate cancer”

Fellowship type: Incoming

Year awarded: 2019

Ribeiro da Cruz Pereira José Rui

Universidade do Minho, Portugal

“Nanomedicine targeting Medulloblastoma in a novel xenotransplant model in wild type mice”

Fellowship type: Outgoing

Year awarded: 2019

Scelfo Andrea

Institut Curie, France

“Elucidating the role of centromere dysfunction in the onset of genomic instability and cell transformation”

Fellowship type: Outgoing

Year awarded: 2018

See the achivement

Silva Raquel

IFOM - Fondazione Istituto FIRC di Oncologia Molecolare, Italy

“Understanding epigenomic regulation rewiring in Diffuse Large B-cell Lymphoma”

Fellowship type: Incoming

Year awarded: 2019

Techer Hervé

Centre National de la Recherche Scientifique, France

“DNA replication stress and inflammation in cancers – focus on SAMHD1 and TREX1”

Fellowship type: Outgoing

Year awarded: 2018

Wong Ee Lin

Università Ca' Foscari di Venezia, Italy

“Macrocyclic peptides targeting unexplored class IIa HDAC binding sites: towards the development of novel cancer therapy.”

Fellowship type: Incoming

Year awarded: 2019

Carrer Alessandro

Fondazione Ricerca Biomedica Avanzata ONLUS
Venetian Institute of Molecular Medicine (VIMM), Italy

“Metabolically-regulated epigenetic landscape in pancreatic cancer initiation”

Fellowship type: Reintegration

Year awarded: 2018

Cerutti Camilla

Istituto Europeo di Oncologia I.R.C.C.S. S.r.l., Italy

“Single-cell epigenetic and molecular signatures in human breast cancer metastasis formation.”

Fellowship type: Reintegration

Year awarded: 2019

Citron Francesca

MD Anderson Cancer Center, USA

“Investigate functional exhaustion of cancer stem cells by targeting the epigenome in pancreatic ductal adenocarcinoma”

Fellowship type: Outgoing

Year awarded: 2019

See the achivement

Corleone Giacomo

Istituti Fisioterapici Ospitalieri (IFO), Italy

“An integrated approach towards uncovering the role of transcription factor engagement in Multiple Myeloma”

Fellowship type: Reintegration

Year awarded: 2019

See the achivement

D'Alessandro Giuseppina

University of Cambridge, England

“Identification and molecular characterization of novel lncRNAs involved in DNA double strand break signaling and repair”

Fellowship type: Outgoing

Year awarded: 2018

Dona Federico

Istituto Europeo di Oncologia I.R.C.C.S. S.r.l., Italy

“The role of Afadin in Wnt dependent planar divisions in normal and cancer intestinal crypts.”

Fellowship type: Reintegration

Year awarded: 2019

Green Brenda

IFOM - Fondazione Istituto FIRC di Oncologia Molecolare, Italy

“Endocytic control of jamming transition: an alternative gateway to cell migration and invasion”

Fellowship type: Incoming

Year awarded: 2018

Locatelli Andrea Giacomo

Fondazione Centro San Raffaele,Italy

“Investigating the unique anti-tumorigenic adaptive strategies evolved in a mammal model of extraordinary longevity.”

Fellowship type: Reintegration

Year awarded: 2019

Manzo Stefano Giustino

Stichting Het Nederlands Kanker lnstituut, Netherlands

“Twisting the boundaries: Role of Topoisomerase1 at the nuclear lamina”

Fellowship type: Outgoing

Year awarded: 2018

Natoni Alessandro

Università degli Studi di Roma "La Sapienza", Italy

“The role of sialofucosylated structures in Myeloma progression and immune evasion”

Fellowship type: Reintegration

Year awarded: 2019

Pasqualetti Francesco

The University of Oxford, England

“Implications of circulating exosomes in patients with glioblastoma”

Fellowship type: Outgoing

Year awarded: 2019

Reis Joana

Università degli Studi di Pavia, Italy

“Drug discovery against carcinogenesis: Design of selective NADPH oxidase inhibitors involved in ROS signalling”

Fellowship type: Incoming

Year awarded: 2018

See the achivement

Sarkar Ankita

Fondazione Istituto Italiano di Tecnologia, Italy

“Dynamic docking simulations to optimize novel and potent anticancer inhibitors of human Topoisomerase II”

Fellowship type: Incoming

Year awarded: 2019

Serra Maria

Istituto di Candiolo - Fondazione del Piemonte per l'Oncologia
(FPO) - I.R.C.C.S., Italy

“The role of metabolic reprogramming in driving colorectal carcinoma by regulating stemness and tumorigenesis”

Fellowship type: Incoming

Year awarded: 2018

Tasselli Luisa

Università degli Studi di Perugia, Italy

“Identification and functional characterization of mutations in the coding and non-coding genome of Hodgkin lymphoma”

Fellowship type: Reintegration

Year awarded: 2019

Transferable skills

As highlighted in the European Charter of Researchers training in non-research oriented skills is essential to develop abilities that make researchers more valuable in the job market, expanding their career opportunities also in non-academic sectors.
Transferable skills include science communication, grant writing, Intellectual Property Rights, entrepreneurship, leadership, research integrity, and many more.

Within iCARE-2 program a dedicated budget (€ 1800/year) is transferred to the Hosting Institution and must be used for meetings and/or training events.

Publicly available training events on transferable skills as well as relevant tools will be advertised in this page: check it regularly!

Events

EMBO Laboratory Management Course: Project Management for Scientists


Date: Several dates available
Host/Organizer: EMBO
Location: Leimen - Germany (near Heidelberg)

The successful management of research projects is key to success in science. This course introduces key concepts in project management, both for planning and managing work, and for working effectively with people (including with yourself).

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EMBO Laboratory Management Course: Self-Leadership for Women Scientists


Date: Several dates available
Host/Organizer: EMBO
Location: Leimen - Germany (near Heidelberg)

This course aims to give women specific support, advice and tools to use in their leadership roles. It is intended for senior postdocs and group leaders.

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EMBO Laboratory Management Course: Negotiation for Scientists


Date: Several dates available
Host/Organizer: EMBO
Location: DE-Leimen (near Heidelberg)

This workshop focuses on negotiation. Participants will gain an understanding and mastery of the negotiation process, which will support them in reaching their professional as well as private goals, and in building lasting partnerships.

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EMBO Laboratory Management Course: Laboratory Leadership for Postdocs


Date:Several dates available
Host/Organizer: EMBO
Location: DE-Leimen (near Heidelberg)

The aim of this 3-day course is to explore with attendees their own approach to leadership – and the approaches of the other participants - and use this insight to define for each individual how they want to lead and manage their research groups or other teams. The course also provides insight into how teams work best together and how to identify and resolve barriers to the efficient operation of teams. Throughout the course, the trainers provide tools, techniques and insight tailored specifically to the laboratory/research setting for the management of teams, good communication, healthy resolution of conflict and the management of workloads and responsibilities.

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Career Management for Early Career Academic Researchers


Date:-
Host/Organizer: Future Learn
Location: Online

Career Management for Early Career Academic Researchers" is an excellent free on-line course (MOOC) available to all PhD students and postdocs. It's due to run from 27th January 2020

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Research Ethics


Date: 14/12/2020 - 16/12/2020
Host/Organizer: -
Location: Online course

This interactive course will explore ethical issues that arise in research & how to tackle them.

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Tools

The Marie Curie Alumni Association


If funded with an iCARE-2 fellowship, you get the right to register in the Marie Curie Alumni Association, a global network of researchers.

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Ten simple rules for collaboratively writing a multi-authored paper


This publication (available as open access) suggests ten rules to collaboratively write a multi-authored paper.

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Think. Check. Submit.


The website Think. Check. Submit. helps researchers identify trusted journals for their research.

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How to design a winning fellowship proposal


This publication (available online free of charge) give some advice on how to plan a fellowship application.

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Why you should move country


Researchers who are mobile get more citations and build broader teams of collaborators than those who aren’t, study finds.

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Open Access to scientific publications and research data in Horizon 2020: Frequently Asked Questions (FAQs)


This fact sheet is written as a frequently asked questions (FAQ) document, in order to answer the queries from Horizon 2020 applicants.

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Making the Right Moves: A Practical Guide to Scientific Management for Postdocs and New Faculty, Second Edition


This book (available for free as a downloadable PDF document) is a collection of practical advice and experiences from seasoned biomedical investigators and includes chapters on laboratory leadership, getting funded, project management, and teaching and course design.

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Film and television tell children who can be scientists


Short article in the Career News section of Nature (23 November 2018)

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Thinking about moving abroad for work? Here’s what the latest research says about the pros and cons of relocating. From Science Careers


Considering going abroad for work? Recent research can help you weigh the pros and cons

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Meet the supervisors who helped to shape four scientists’ careers


Knowing when to hand-hold and when to step back is crucial for helping early-career researchers.

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Seven steps to boost your research career in 2019


If you’re looking to move labs, countries or sectors this year, or seeking general career inspiration, here’s some advice from five researchers who featured in Nature Careers in 2018.

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Conference attendance boosts authorship opportunities


Scientists who travel to meetings are more likely to co-author papers than are those who stay at home.

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Six project-management tips for your PhD


Use strategies from the private sector to better manage your graduate project. …valide also for your Post-Doc!

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Conference presentations: Lead the poster parade


An eye-catching presentation can attract potential collaborators — and even a cash prize.

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Working Scientist podcast: How to plan a successful grant application


Julie Gould investigates the importance of advance planning when you're preparing a funding application.

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My first postdoc position was a disaster. This is what I learned


Some tips of moving on from a bad postdoc position.

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To ace your Ph.D. program interviews, prepare to answer—and ask—these key questions


You’ve made it to the last step of the Ph.D. application process: the interview.

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Essential elements for high-impact scientific writing


Successfully communicating the impact of your research is crucial for making your work more accessible, and for career progression. Here are the key elements to make your data stand out.

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How to use Twitter to further your research career


The social-media platform is often a tool for procrastination. But what else can it be?.

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Why I plan my career in pencil—not pen


Career plans can change: write your goals in pencil, and be preparared to change them.

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The Node


This page lists events that are of interest to the global community of (developmental) biologists: conferences, meetings, training courses, workshops.

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Peer Review: the nuts and bolts


This is a guide to peer review for early career researchers written by members of the VoYS network. Using a collection of concerns raised by their peers, the authors set off to interview scientists, journal editors, grant bodies’ representatives, patient group workers and journalists in the UK and around the world to find out how peer review works, the challenges for peer review and how to get involved.

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To find the right career fit, I needed to do more than move from job to job


"I spent a few years in each role only to find that it wasn’t quite the right fit." When this scientist couldn’t find her one ideal job, she tried something different: a combination of two.

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Three research-based lessons to improve your mentoring


How to become a better mentor in this "Letters to Young Scientists" column from Science Careers.

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Six easy ways to manage your time better


The amount and quality of what you achieve are crucially dependent on how effectively you manage your time. Andrew C. Johnson and John Sumpter propose some simple steps that scientists can take to improve their time management.

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Five ways media training helped me to boost the impact of my research


How I learnt to maximize the value of TV, radio and publication interviews to reach and help the people I most want to support.

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The importance of being introspective in the lab


Question your own point of view first to avoid career-damaging conflict, says Benjamin Tsang.

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The professional advisers who can help you to move from academia to industry


University careers advisory services can connect PhD students with employers and guide them to the right role.

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Essential elements for high-impact scientific writing


To write better, remember that your science is exciting, says Eric J. Buenz.

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How to write effectively for international journals


Use modern tools to manage research literature, analyse published articles and find language teachers to improve manuscripts for publication.

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Postdoctoral mentorship key to career success


Mentors can have a lasting influence, but it’s important to carve your own niche.

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Tenure denial, and how early-career researchers can survive it


Scientists with first-hand experience of rejection offer their advice.

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Renowned fellowships aren’t the only option


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Five reasons to do an internship during your PhD programme


Rekindle your love for problem-solving by taking your lab skills to a completely different environment, says Jessica Sagers.

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Top tips for giving an engaging talk


Three researchers share lessons they’ve learnt from presenting at TED conferences.

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How agile project management can work for your research


Laura Pirro outlines an approach that could increase output and improve motivation.

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Networking for introverted scientists


A structured, scientific approach can help introverted scientists to become networking superstars, says academic educator Ruth Gotian. She outlines how to prepare effectively, the three things you should aim to achieve at a networking event and how to find networking spaces that work best for you.

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The Mentor Protégé Partnership: How to Leverage This Critical Alliance


How do you sustain and grow a mentoring relationship for the long term? Find out in this free webinar organized by the Lindau Nobel Laureate Meetings, presented by Alaina G. Levine.

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Cell mentor


From CellPress, Cell Mentor empowers early-career researchers with career insights, publishing advice, and techniques on experimental processes and procedures.

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Toolkit: How to find scientific funding


An early career researcher’s guide to the working world of science, from Nature Careers.Your science has to be good to attract funding. Competition is fierce, but there are techniques you can use to boost your chances of securing a grant.

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Toolkit: How to write a great paper


An early career researcher’s guide to the working world of science, from Nature Careers. Excellent science is an essential ingredient of any great research paper, but concise writing and a clear structure are also crucial.

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Toolkit: How to write a great academic CV


An early career researcher’s guide to the working world of science, from Nature Careers. Academic CVs differ from those intended for industry roles. Here are some broad rules to follow.

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How academics should use Twitter


Scientists are pushing back against the kind of university social-media guidelines that stifle their voices and bury the “power of the individual”, says geneticist Piero Carninci. Rather than opt out altogether, try this neat guide to help scientists — as well as their higher-ups — get over the Twitter jitters.

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Three tips to avoid becoming a ‘conference zombie’


It’s tempting to try to attend sessions morning, noon and night, network like crazy during every ‘spare’ minute and drink vats of coffee to stay alert. Paris H. Grey has more realistic suggestions to get maximum value from any conference.

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Ways to give an effective seminar about your research project


In this Nature Career article, Ananya Sen recommends to grab your audience’s attention by using slides as a roadmap and focusing on your role as a presenter.

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Research integrity is much more than misconduct


Nature editorial: All researchers should strive to improve the quality, relevance and reliability of their work.

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Is the Earth flat? A six-step guide to better communicate your scientific results to the public


Useful article of the Marie Curie Alumni Association Blog.

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ACS Careers Network


The ACS Career Navigator™ guides you in exploring the career roles you aspire to and provides the resources necessary to function effectively in each role.

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New Scientists Jobs


Career advice from New Scientist.

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Help funders help you: Five tips for writing effective funding applications


Letter to young scientists.

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How to get your abstract selected for a short talk at a conference


In this short video prepared by EMBL, find out how you can increase your chances of getting selected for a short talk at your next conference, by answering 4 basic questions.

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The science institutions hiring integrity inspectors to vet their papers


This News Feature article from Nature describes recent procedures put in place by some research institution to foster research integrity.

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Recommended checklist for researchers


Prepared by the UK Integrity Office, the Recommended checklist for Researchers is a one-page, non-technical chelist of key-points of good practice in research , applicable to all research areas.

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Think. Check. Attend


Think. Check. Attend. is an initiative that aims to guide and assist researchers and scholars to judge the legitimacy and academic credentials of conferences in order to help them decide whether to or not attend the same.

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Experi-mentoring: Where to turn when your PI can’t help


In this Science Career story, Adam Ruben describes few possible alternative sources of mentorship, when your PI is unavailable to mentor you.

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Tips for fruitful networking over the holidays


In this Science Career story, Alaina G. Levine give some advice on how to The holiday season is also the perfect time for networking from afar. It gives you a reason to reach out and say hello, to follow up on a conversation you had in the last year, or to reconnect with someone you haven’t interacted with in a while.

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Predatory journals: no definition, no defence


Leading scholars and publishers from ten countries have agreed a definition of predatory publishing that can protect scholarship. It took 12 hours of discussion, 18 questions and 3 rounds to reach.

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No country for bad science writing


Pulitzer-prizewinning novelist Cormac McCarthy has edited many works by faculty members and postdocs at the Santa Fe Institute in New Mexico, including theoretical biologist and ecologist Van Savage. In bite-size pieces relevant to academics and humble email-writers alike, Savage summarizes the advice he got from McCarthy over a winter of lively weekly lunches. McCarthy’s most important tip: keep it simple while telling a coherent, compelling story.

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How to get your work on a journal cover


First, do some great science, obviously. Next, heed the advice of scientific photographer Felice Frankel and learn to take an exceptional photo using only a mobile phone or a flatbed scanner. Kelly Krause, creative director of Nature and the Nature journals, walks you through some of the stunning images and top tips from Frankel’s latest book.

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Six project-management tips for your PhD


A PhD project can feel like it demands more time than is humanly possible. PhD candidate Angel Santiago-Lopez came up with a list of project-management skills that could help you to tame the beast.

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What not to do in graduate school


Chemist Buddini Karawdeniya offers simple but sound advice for graduate students (and it’s quite handy for the rest of us, too). Don’t compare yourself with others, blindly trust your data or get stuck after one failure. And, when you struggle with problems, don’t suffer alone.

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Articles in ‘predatory' journals receive few or no citations


Science article on the citation level of articles published on "predatory" journals.

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Check for publication integrity before misconduct


This Nature comment presents a tool that focuses on papers — not researcher behaviour — and that can help readers, editors and institutions assess which publications to trust.

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Twelve tips for engaging with biologists, as told by a physicist


In this Nature Career column article, Sarah Bohndiek says that the fastest way to become fluent in the language of a new scientific discipline is to embed yourself inside it and use it regularly.

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Top tips for getting your science out there


In this Nature Career column article, Craig Cormick explains how scientists can get their arguments across to members of the public.

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What to do when your grant is rejected


Failed funding applications are inevitable, but perseverance can pay dividends.

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A scientist’s guide to email etiquette


This Letters to Young Scientists articles offers tips on how to get the most out of email communication.

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Ten Simple Rules to becoming a principal investigator


From bouncing back from failure to knowing when to quit, immunologist John Tregoning and computational biologist Jason McDermott outline ten tips for overcoming “the biggest choke point in an academic career … moving from doing someone else’s research to getting other people to do yours”. With cartoons!

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Safety First: A Recent Case of a Dichloromethane Injection Injury


When a tiny lab accident almost leads to amputation. A student in Sébastien Vidal’s lab accidentally stabbed himself with a syringe containing a residual amount of dichloromethane, one of the most common organic solvents used in a synthetic chemistry laboratory. The student almost lost his finger. Vidal shares a first-hand account of the accident (with somewhat gruesome photos of the injured finger) to spread the word of the danger of this compound and urge the scientific community to develop safer methods.

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Science 2020 Career Handbook


Science Careers has teamed up with some great organizations to bring you information about the latest career opportunities in many different fields. The profiles included in this booklet give you a sense of the types of organizations that are accepting resumes and the kinds of positions they offer. We’ve also included some articles with some general tips and advice on job searching.

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Free lists of grants and fellowships around the world available online


Three searchable databases provide information on global opportunities for graduate students, postdocs and junior faculty members.

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Words matter: jargon alienates readers


Overly technical language in science articles can alienate readers, potentially shutting them out of scientific discussion and knowledge. A study of 650 members of the general public found that jargon-packed paragraphs made topics harder to understand, and discouraged them from finding out more, compared to text that used more familiar words. Adding links to define technical terms didn’t help — better to avoid jargon at all, say the researchers.

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Taking Pleasure in Networking


Want to improve your networking skills? This MCAABlog post provides some valuable tips on networking for scientists and researchers

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Research integrity: 9 ways to walk the walk


Over the past two decades, there have been plenty of declarations that outline the components of trustworthy research and the principles of research integrity. There have also been shocking cases of fraud, alarming rates of questionable research practices and foot-dragging on retractions and corrections, write political scientist Niels Mejlgaard and 20 colleagues. Their long-term study on improving research integrity reveals nine ways institutions are trying to make things better, from preventing hypercompetition to offering incentives for data sharing.

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How to make great CVs for industry and academia


This webcast, the first of a two-part series, will aim to help PhD students and other early career researchers improve their CVs for their future careers. It will touch on both academic and industry research CVs, and the differences between them.

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Fellows' scientific achievements

AIRC wants to give visibility to the scientific production of iCARE-2 fellows.
This page will host a link to all the scientific achievements produced during the fellowship’s period, such as papers, patents and conference proceedings.

Keeping the Centromere under Control: A Promising Role for DNA Methylation.

Scelfo A (iCARE-2 2018), Fachinetti D.


Cells. 2019 Aug 16;8(8). pii: E912. doi: 10.3390/cells8080912. Review. Read article here

Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy.

Desideri E (iCARE-2 2018), Ciccarone F, Ciriolo MR.


Nutrients . 2019 Aug 16;11(8). pii: E1926. doi: 10.3390/nu11081926. Review. Read article here

Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression.

Tamburri S, Lavarone E, Fernández-Pérez D, Conway E (iCARE-2 2018), Zanotti M, Manganaro D, Pasini D.


Mol Cell. 2019 Dec 17. pii: S1097-2765(19)30890-1. doi: 10.1016/j.molcel.2019.11.021. Read article here

A closer look into NADPH oxidase inhibitors: Validation and insight into their mechanism of action

J. Reis (iCARE-2 2018), M. Massari, S. Marchese, M. Ceccon, F.S. Aalbers, F. Corana,S. Valente, A. Mai, F. Magnani, A. Mattevi.


Redox Biology (2020), doi: 10.1016/j.redox.2020.101466. Read article here

Helper Innate Lymphoid Cells in Human Tumors: A Double-Edged Sword?

Tumino N, Vacca P, Quatrini L (iCARE-2 2018), Munari E, Moretta F, Pelosi A, Mariotti FR, Moretta L.


Front Immunol. 2020 Jan 29;10:3140, doi: 10.3389/fimmu.2019.03140. eCollection 2019. Review Read article here

Characterisation of innate lymphoid cell subsets infiltrating colorectal carcinoma.

Carrega P, Orecchia P, Quatrini L (iCARE-2 2018), Tumino N, Venè R, Benelli R, Poggi A, Scabini S, Mingari MC, Moretta L, Vacca P.


Gut. 2020 Mar 5. pii: gutjnl-2020-320908. doi: 10.1136/gutjnl-2020-320908. Read article here

Role of uL3 in the Crosstalk between Nucleolar Stress and Autophagy in Colon Cancer Cells

Pecoraro A, Carotenuto P (iCARE-2 2019), Franco B, De Cegli R, Russo G, Russo A.


Int J Mol Sci. 2020 Mar 20;21(6). pii: E2143. doi: 10.3390/ijms21062143 Read article here

ILC3s: Rhythmic Keepers of Gut Integrity at Mealtime

Quatrini L (iCARE-2 2018) , Moretta L , Mingari MC


Trends Immunol . 2020 Apr 16;S1471-4906(20)30065-X. doi: 10.1016/j.it.2020.03.011. Read article here

Glucocorticoids and the cytokines IL-12, IL-15 and IL-18 present in the tumor microenvironment induce PD-1 expression on human Natural Killer cells.

Quatrini L (iCARE-2 2018), Vacca P, Tumino N, Besi F, Di Pace AL, Scordamaglia F, Martini , Munari E, Mingari MC, Ugolini S, Moretta L.


J Allergy Clin Immunol. 2020 May 14. pii: S0091-6749(20)30646-1. doi: 10.1016/j.jaci.2020.04.044. [Epub ahead of print] Read article here

PMN-MDSC are a new target to rescue graft-versus-leukemia activity of NK cells in haplo-HSC transplantation.

Tumino N, Besi F, Di Pace AL, Mariotti FR, Merli P, Li Pira G, Galaverna F, Pitisci A, Ingegnere T, Pelosi A, Quatrini L (iCARE-2 2018), Munari E, Locatelli F, Moretta L, Vacca P.


Leukemia. 2020 Mar;34(3):932-937. doi: 10.1038/s41375-019-0585-7. Epub 2019 Oct 4. PMID: 31586150; PMCID: PMC7214239 Read article here

NK cells and ILCs in tumor immunotherapy.

Sivori S, Pende D, Quatrini L (iCARE-2 2018), Pietra G, Della Chiesa M, Vacca P, Tumino N, Moretta F, Mingari MC, Locatelli F, Moretta L.


Mol Aspects Med. 2020 Aug 13:100870. doi: 10.1016/j.mam.2020.100870. Epub ahead of print. PMID: 32800530 Read article here

New insights into the cell- and tissue-specificity of glucocorticoid actions

Sivori S, Pende D, Quatrini L (iCARE-2 2018), Pietra G, Della Chiesa M, Vacca P, Tumino N, Moretta F, Mingari MC, Locatelli F, Moretta L.


Mol Aspects Med. 2020 Aug 13:100870. doi: 10.1016/j.mam.2020.100870. Epub ahead of print. PMID: 32800530 Read article here

Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer.

Sivori S, Della Chiesa M, Carlomagno S, Quatrini L, Munari E, Vacca P, Tumino N, Mariotti FR, Mingari MC, Pende D, Moretta L.


Front Immunol. 2020 Sep 3;11:2156. doi: 10.3389/fimmu.2020.02156. PMID: 33013909; PMCID: PMC7494755 Read article here

Immune surveillance of the liver by T cells.

Ficht X (iCARE-2 2019), Iannacone M.


Sci Immunol. 2020 Sep 4;5(51):eaba2351. doi: 10.1126/sciimmunol.aba2351. PMID: 32887842 Read article here

An Elegant Four-Helical Fold in NOX and STEAP Enzymes Facilitates Electron Transport across Biomembranes-Similar Vehicle, Different Destination

Oosterheert W, Reis J (iCARE-2 2018), Gros P, Mattevi A.


Acc Chem Res. 2020 Sep 15;53(9):1969-1980. doi: 10.1021/acs.accounts.0c00400. Epub 2020 Aug 20. PMID: 32815713 Read article here

Leukotrienes, a potential target for Covid-19.

Citron F (iCARE-2 2019), Perelli L, Deem AK, Genovese G, Viale A.


Prostaglandins Leukot Essent Fatty Acids. 2020 Oct;161:102174. doi: 10.1016/j.plefa.2020.102174. Epub 2020 Sep 17. PMID: 32977289; PMCID: PMC7495247. Read article here

Helper Innate Lymphoid Cells in Allogenic Hematopoietic Stem Cell Transplantation and Graft Versus Host Disease.

Quatrini L (iCARE-2 2018), Tumino N, Moretta F, Besi F, Vacca P, Moretta L.


Front Immunol. 2020 Sep 30;11:582098. doi: 10.3389/fimmu.2020.582098. PMID: 33101308; PMCID: PMC7554507. Read article here

ssRNA Virus and Host Lipid Rearrangements: Is There a Role for Lipid Droplets in SARS-CoV-2 Infection?

Pagliari F, Marafioti MG, Genard G, Candeloro P, Viglietto G, Seco J, Tirinato L.(iCARE-2 2018)


Front Mol Biosci. 2020 Oct 8;7:578964. doi: 10.3389/fmolb.2020.578964. PMID: 33134318; PMCID: PMC7579428. Read article here

The Immune Checkpoint PD-1 in Natural Killer Cells: Expression, Function and Targeting in Tumour Immunotherapy.

Quatrini L (iCARE-2 2018), Mariotti FR, Munari E, Tumino N, Vacca P, Moretta L.


Cancers (Basel). 2020 Nov 6;12(11):E3285. doi: 10.3390/cancers12113285. PMID: 33172030 Read article here

Raman Spectroscopic Stratification of Multiple Myeloma Patients Based on Exosome Profiling.

Russo M, Tirinato L (iCARE-2 2018), Scionti F, Coluccio ML, Perozziello G, Riillo C, Mollace V, Gratteri S, Malara N, Di Martino MT, Viglietto G, Tagliaferri P, Tassone P, Rossi M, Candeloro P.


ACS Omega. 2020 Nov 18;5(47):30436-30443. doi: 10.1021/acsomega.0c03813. PMID: 33283091; PMCID: PMC7711702. Read article here

ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal

Tirinato L (iCARE-2 2018), Pagliari F, Di Franco S, Sogne E, Marafioti MG, Jansen J, Falqui A, Todaro M, Candeloro, Liberale C, Seco J, Stassi G, Di Fabrizio E.


Cancer Stem Cells. Genes & Diseases. 2020; 7(4):620-635, doi.org/10.1016/j.gendis.2019.09.010 Read article here

Synthetic Lethal Screens Reveal Co-Targeting FAK and MEK as a Multimodal Precision Therapy for GNAQ-Driven Uveal Melanoma.

Paradis JS, Acosta M, Saddawi-Konefka R, Kishore A, Lubrano S (iCARE-2 2019), Gomes FG, Arang N, Tiago M, Coma S, Wu X, Ford K, Day CP, Merlino G, Mali P, Pachter JA, Sato T, Aplin AE, Gutkind JS.


Clin Cancer Res. 2021 Feb 10:clincanres.3363.2020. doi: 10.1158/1078-0432.CCR-20-3363. Epub ahead of print. PMID: 33568347. Read article here

Inhibition of JNK increases the sensitivity of hepatocellular carcinoma cells to lysosomotropic drugs via LAMP2A destabilization.

Desideri E (iCARE-2 2018), Ciriolo MR.


Cell Death Discov. 2021 Feb 8;7(1):29. doi: 10.1038/s41420-021-00408-0. PMID: 33558496. Read article here

Integrated Genomics Identifies miR-181/TFAM Pathway as a Critical Driver of Drug Resistance in Melanoma.

Barbato A, Iuliano A, Volpe M, D'Alterio R, Brillante S, Massa F, De Cegli R, Carrella S, Salati M, Russo A, Russo G, Riccardo S, Cacchiarelli D, Capone M, Madonna G, Ascierto PA, Franco B, Indrieri A, Carotenuto P. (iCARE-2 2019)


Int J Mol Sci. 2021 Feb 11;22(4):1801. doi: 10.3390/ijms22041801. PMID: 33670365; PMCID: PMC7918089 Read article here

Interaction Between MDSC and NK Cells in Solid and Hematological Malignancies: Impact on HSCT

Tumino N, Di Pace AL, Besi F, Quatrini L (iCARE-2 2018), Vacca P, Moretta L.


Front Immunol. 2021 Feb 12;12:638841. doi: 10.3389/fimmu.2021.638841. PMID: 33679798; PMCID: PMC7928402 Read article here

The Pervasive Role of the miR-181 Family in Development, Neurodegeneration, and Cancer.

Indrieri A, Carrella S, Carotenuto P (iCARE-2 2019), Banfi S, Franco B.


Int J Mol Sci. 2020 Mar 18;21(6):2092. doi: 10.3390/ijms21062092. PMID: 32197476; PMCID: PMC7139714 Read article here

Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma.

Bruno T, De Nicola F, Corleone G (iCARE-2 2019) , Catena V, Goeman F, Pallocca M, Sorino C, Bossi G, Amadio B, Cigliana G, Ricciardi MR, Petrucci MT, Spugnini EP, Baldi A, Cioce M, Cortese G, Mattei E, Merola R, Gianelli U, Baldini L, Pisani F, Gumenyuk S, Mengarelli A, Höpker K, Benzing T, Vincenzi B, Floridi A, Passananti C, Blandino G, Iezzi S, Fanciulli M


Blood Adv. 2020 Nov 24;4(22):5616-5630. doi: 10.1182/bloodadvances.2020002566. PMID: 33186461; PMCID: PMC7686885. Read article here

Inhibitory checkpoints in human natural killer cells: IUPHAR Review 28.

Mariotti FR, Quatrini L (iCARE-2 2018), Munari E, Vacca P, Tumino N, Pietra G, Mingari MC, Moretta L


Br J Pharmacol. 2020 Jul;177(13):2889-2903. doi: 10.1111/bph.15081. Epub 2020 May 18. PMID: 32335915; PMCID: PMC7279970. Read article here

Human NK cells, their receptors and function.

Quatrini L (iCARE-2 2018), Chiesa MD, Sivori S, Mingari MC, Pende D, Moretta L.


Eur J Immunol. 2021 Apr 26. doi: 10.1002/eji.202049028. Epub ahead of print. PMID: 33899224. Read article here

NK Cells and PMN-MDSCs in the Graft From G-CSF Mobilized Haploidentical Donors Display Distinct Gene Expression Profiles From Those of the Non-Mobilized Counterpart.

Pelosi A, Besi F, Tumino N, Merli P, Quatrini L (iCARE-2 2018), Li Pira G, Algeri M, Moretta L, Vacca P.


Front Immunol. 2021 Apr 27;12:657329. doi: 10.3389/fimmu.2021.657329. PMID: 33986748; PMCID: PMC8111072 Read article here

A Novel Analysis Method for Evaluating the Interplay of Oxygen and Ionizing Radiation at the Gene Level.

Jansen J, Vieten P, Pagliari F, Hanley R, Marafioti MG, Tirinato L (iCARE-2 2018), Seco J.


Front Genet. 2021 Apr 28;12:597635. doi: 10.3389/fgene.2021.597635. PMID: 33995470; PMCID: PMC8113813. Read article here